Retin-A (tretinoin) is a topical medication specially designed for the treatment of acne that affects the condition of your skin and can lead to scarring if not treated properly. Retin-A is supposed to be applied regularly, usually once a day in the evening before going to bed. You need to apply the medication using dry clean hands, or a cotton swab if you are using the liquid form. It's important to avoid oversaturation (applying more than needed), as it is not likely to make your acne get better sooner. You will need to apply a small amount of this medicine to the area affected by the acne (or where the acne usually appears). It's important that you cleanse the skin properly before this procedure to make sure there is no make up or skin oil. If you notice no improvement - continue applying Retin-A anyway, as it takes some time for the first effects to appear. When you notice the improvement, do not stop the therapy as the effects achieved are supposed to be maintained. Such side effects as stinging, itching, peeling, dry skin, burning, and redness are pretty normal and need to be reported to your doctor only if they get more severe and do not disappear in the morning. Make sure you let your doctor know if you experience blistering, redness, abnormal irritation, peeling of the skin, and any other severe reactions every single time you apply Retin-A, as these reactions of your skin can mean something is not being done right. Avoid applying any preparations containing sulfur, salicylic acid, preparations containing benzoyl peroxide, as well as resorcinol along with Retin-A, as this can be too much for your skin to handle. It's generally recommended to let your skin "rest" between the medicines mentioned. The effects of Retin-A on pregnant or breastfeeding women have not been properly studied, which is why such women should not start the treatment without previously discussing all the risks and benefits with their health care provider. Retin-A can make your skin more sensitive to sunburns, which may result in skin reactions if you stay outside for a long time without applying sun screen or wearing protective clothing. The following drugs can add to the side effects of Retin-A, and are therefore not supposed to be used simultaneously with it: certain antibiotics, tranquilizers, sulfa drugs, or water pills. Please make sure you know for sure whether drugs you are taking at the moment or intend to take can be safely combined with Retin-A.